GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs6705489 | chr2:73648811 | ALMS1P | chr2:73872046-73912692:+ | 0.61 | 4.73 | 7.71E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs6707722 | chr2:73654363 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs4372836 | 1 | rs6707848 | chr2:28988083 | TRMT61B | chr2:29072690-29093175:- | -0.53 | -4.42 | 2.62E-5 | Body mass index |
| THYM | cis | rs2288073 | 1 | rs6708328 | chr2:24412413 | LOC375190 | chr2:24299728-24397519:+ | -0.33 | -4.67 | 9.95E-6 | Venous thromboembolism (SNP x SNP interaction) |
| THYM | cis | rs60843830 | 1 | rs6709534 | chr2:217334 | SH3YL1 | chr2:218138-264810:- | -0.29 | -4.18 | 6.49E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9309473 | 1 | rs6710438 | chr2:73820108 | ALMS1P | chr2:73872046-73912692:+ | -0.59 | -4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs6711033 | chr2:73746643 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 4.34 | 3.62E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs6715819 | chr2:73772309 | ALMS1P | chr2:73872046-73912692:+ | 0.55 | 4.17 | 6.71E-5 | Metabolite levels |
| THYM | cis | rs1559040 | 1 | rs6721034 | chr2:54347307 | RTN4 | chr2:55199329-55277734:- | -0.5 | -4.14 | 7.39E-5 | Sudden cardiac arrest |
| THYM | cis | rs3820928 | 1 | rs6723774 | chr2:227770592 | RHBDD1 | chr2:227700773-227861591:+ | 0.31 | 4.5 | 1.93E-5 | Pulmonary function |
| THYM | cis | rs9309473 | 1 | rs6724782 | chr2:73679990 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.72 | 8.0E-6 | Metabolite levels |
| THYM | cis | rs7597155 | 1 | rs6727897 | chr2:69987384 | GMCL1 | chr2:70056818-70106727:+ | 0.14 | 4.99 | 2.73E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| THYM | cis | rs1875620 | 1 | rs67308794 | chr9:91560222 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs4663866 | 1 | rs6734408 | chr2:239137481 | LOC151174 | chr2:239133754-239140318:- | 0.92 | 4.63 | 1.14E-5 | Irritable bowel syndrome |
| THYM | cis | rs9309473 | 1 | rs6736866 | chr2:73661986 | ALMS1P | chr2:73872046-73912692:+ | 0.64 | 4.83 | 5.14E-6 | Metabolite levels |